How can we promote standards in polygenic and integrated risk score development and reporting of results to enable assessments of analytic validity, clinical validity and clinical utility?
- Create a standardized reporting guideline for adequate transparency, reproducibility, and interpretability of published polygenic risk score, especially with respect to enabling downstream clinical implementation.
- Collaborate with individual institutions and other consortia to promote shared language and guidelines for data sharing and evaluation of polygenic risk scores.
- Leverage existing principles in epidemiology and risk modeling to advance polygenic risk scores as a clinical tool for risk prediction, while recognizing the unique considerations for assessing utility and actionability.
Working Group Membership
Membership spans many fields, including genetics, medical, academia, and industry.