Somatic Variant Curation

The ClinGen somatic cancer curation process involves evaluating the strength of evidence supporting or refuting the clinical significance (i.e. therapeutic, prognostic and diagnostic effect) of somatic variants in different cancer types, using the AMP/ASCO/CAP guidelines, and the MVLD data representation of cancer variants.

The ClinGen Somatic Cancer Working Group (WG) aims to collaborate with expert groups such as the Association of Molecular Pathologists (AMP), the College of American Pathologists (CAP) and the American Society of Clinical Oncology (ASCO), as well as expert curated and harmonized knowledgebases including CIViC, ClinVar, and the GA4GH VICC-metaKB, to develop processes that support

  • Accurate determination of the clinical significance of somatic changes in cancer for use by physicians, clinical laboratories, researchers, and guideline-developing groups

  • Enhance the usability, dissemination and implementation of somatic changes in cancer to improve patient care through genomic medicine.

The ClinGen Somatic Cancer WG uses an open source, web-based platform called CIViC (Clinical Interpretations of Variants in Cancer) to curate the clinical significance of somatic variants in cancer. 

Training Materials

Training videos and SOP documents available for those interested in Somatic Variant Curation.

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Documents & Announcements

Documents and announcements related to Somatic Variant Curation

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Somatic Variant Curation Interface

  • Click on the Sign In/ Sign Up button on the Top Right of the webpage
  • You can sign-in using your Google ID, ORCID or GitHub ID
  • Email CIViC and request them to associate your account with the ClinGen Somatic Organization

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