Clinical Actionability Training Materials
Interested in Clinical Actionability? The following documents and presentations are available to help people learn and understand the Clinical Actionability curation process. In order to get involved with our Clinical Actionability activities, please fill out our volunteer survey: http://bit.ly/clingenvolunteersurvey. For questions about existing materials or requests for new materials, contact us at email@example.com.
Publication: Official ClinGen Clinical Actionability Method
Read the publication describing the ClinGen clinical actionability evaluation process (freely available through PubMed Commons).
Semi-quantitative Scoring Metric
Specific outcome-intervention pairs are scored for (i) severity of the outcome; (ii) likelihood of the disease; (iii) effectiveness of the intervention; and (iv) nature of the intervention in terms of burden and risk to the patient. The Semi-Quantiative Metric used by the ClinGen Actionability group is based on a similar metric developed for the NCGENES project. Read the publication here (freely available through PubMed Commons).
Evidence Synthesis Protocol
The Evidence Synthesis Protocol used by the ClinGen Actionability work group is based on methods developed by EGAPP. Read the publication here (freely available through PubMed Commons).
Actionability Workgroup Protocols
Clinical Actionability Overview Slides
Overview of the clinical actionability evaluation process, prepared February 2017