One specific goal of ClinGen is to develop teams of experts in different clinical domains to evaluate the clinical validity of gene-disease relationships and pathogenicity of individual genetic variants.

About Gene Curation Expert Panels
Gene Curation Expert Panels implement an approved process of evaluating the strength of evidence supporting or refuting a claim that variation in a particular gene causes a particular disease.

Interested in volunteering to curate for ClinGen? Please take this brief survey to tell us more about your interests, expertise, and desired level of involvement so we can pair you with an appropriate curation activity and/or Expert Panel. 

Interested in starting an Expert Panel? See our guidelines for applying for Gene Curation Expert Panel Status.

About Variant Curation Expert Panels
Variant Curation Expert Panels evaluate evidence to classify a genomic variant on a spectrum from pathogenic to benign with respect to a particular disease and inheritance pattern.

Interested in volunteering to curate for ClinGen? Please take this brief survey to tell us more about your interests, expertise, and desired level of involvement so we can pair you with an appropriate curation activity and/or Expert Panel. 

Interested in starting an Expert Panel? See our guidelines for applying for Variant Curation Expert Panel Status.